Aciron-500 Injection
Acyclovir 500 mg Lyophilised Powder for Injection — Antiviral Therapy
| Composition | Acyclovir 500 mg (Lyophilised) |
|---|---|
| Dosage Form | Injection (IV) |
| Pack Type | Vial + Water for Injection |
| Pack Size | 1 Vial of 500 mg + WFI |
| MRP | ₹ 602 |
| Therapy | Injectable / Antibiotic / Dermatology — Antiviral (Nucleoside Analogue) |
| Storage | Store below 25 °C, protect from light. Once reconstituted, use within 12 hours. |
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About Aciron-500 Injection
Aciron-500 Injection contains 500 mg of lyophilised Acyclovir, the higher-strength intravenous formulation used in adults requiring weight-based dosing for severe herpes virus infections. The single-vial 500 mg presentation reduces reconstitution steps and is convenient in hospital and critical-care settings where rapid initiation of antiviral therapy is essential.
Acyclovir’s selective uptake into virus-infected cells, mediated by viral thymidine kinase, produces a high intracellular concentration of the active triphosphate. This selectively blocks viral DNA polymerase, halting replication of HSV-1, HSV-2 and VZV while leaving uninfected host cells essentially untouched.
Aciron-500 is manufactured by Trumac Healthcare in WHO-GMP certified injectable facilities and is offered for PCD pharma franchise, third-party contract manufacturing and export.
Indications
- Severe and disseminated HSV infection in immunocompromised patients
- HSV encephalitis and neonatal HSV
- Severe varicella
- Herpes zoster in immunocompromised adults
- Prophylaxis of HSV in transplant recipients
Mechanism of Action
Acyclovir requires three sequential phosphorylations to reach its active triphosphate form. Viral thymidine kinase performs the first step preferentially in infected cells; cellular kinases complete the cascade. Acyclovir triphosphate competitively inhibits viral DNA polymerase and incorporates into nascent viral DNA, causing chain termination.
Dosage & Administration
Adults: 5–10 mg/kg body weight every 8 hours by slow IV infusion over at least 1 hour, for 5–10 days. Dose adjustment is required in renal impairment. Adequate hydration must be maintained throughout therapy. To be administered only under qualified medical supervision.
Side Effects
Injection-site reactions, phlebitis, nausea, vomiting, headache, raised serum creatinine, transient hepatic enzyme elevation. Rare: crystalluria with renal impairment, neurotoxicity, thrombocytopenia, anaphylaxis.
Contraindications & Precautions
Hypersensitivity to acyclovir or valacyclovir. Caution in renal impairment, dehydration, the elderly, and in concurrent use with nephrotoxic agents. Ensure adequate hydration to minimise crystalluria risk.
Storage
Store below 25 °C, protect from light. Once reconstituted, use within 12 hours.
Aciron-500 Injection is available for monopoly-based PCD pharma franchise across India and for third-party manufacturing under your brand. WHO-GMP certified, with full visual-aid and promotional support. Become a Trumac franchise partner →
Frequently Asked Questions
What is Aciron-500 Injection used for?
Aciron-500 Injection contains Acyclovir 500 mg and is used in severe HSV infections, HSV encephalitis, neonatal HSV, severe varicella and disseminated herpes zoster.
How is Aciron-500 Injection given?
It is administered as a slow IV infusion over at least one hour, 5–10 mg/kg every 8 hours, by a qualified healthcare professional.
Is Aciron-500 available for PCD pharma franchise?
Yes, Trumac Healthcare offers Aciron-500 Injection on a monopoly-based PCD pharma franchise and for third-party manufacturing.
How should Aciron-500 Injection be stored?
Store below 25 °C, protected from light. Use within 12 hours after reconstitution.
Is Aciron-500 manufactured under WHO-GMP?
Yes, Aciron-500 Injection is manufactured in a WHO-GMP and DCGI-compliant injectable facility.
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