Piozest-15 Tablet

Pioglitazone 15 mg

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About Piozest-15 Tablet

Piozest-15 Tablet contains Pioglitazone 15 mg. Pioglitazone is a thiazolidinedione that improves insulin sensitivity in target tissues by activating PPAR-gamma. It is particularly useful in type-2 diabetes with prominent insulin resistance.

Indicated for type-2 diabetes mellitus, generally as add-on therapy to metformin and/or sulphonylurea, especially in patients with metabolic syndrome features.

Camrut Healthcare manufactures the Piozest range under WHO-GMP conditions for PCD pharma franchise across India.

Indications

• Type-2 diabetes mellitus with insulin resistance
• Type-2 DM with metabolic syndrome
• Add-on to metformin or sulphonylurea
• NAFLD with diabetes (adjunctive)

Mechanism of Action

Pioglitazone is a selective agonist of peroxisome-proliferator-activated receptor gamma (PPAR-γ), a nuclear receptor highly expressed in adipose, muscle and liver. Activation regulates transcription of genes involved in glucose and lipid metabolism — improving peripheral insulin sensitivity, reducing hepatic glucose output and shifting fat storage from visceral to subcutaneous depots.

Dosage & Administration

['Adults: 1 tablet once daily, with or without food', 'Titrate slowly', 'Avoid in heart failure', 'Monitor liver function']

Side Effects

['Weight gain', 'Fluid retention and oedema', 'Heart failure (precipitation/worsening)', 'Increased fracture risk in women', 'Bladder cancer risk (controversial)', 'Macular oedema (rare)']

Contraindications & Precautions

['Heart failure NYHA III-IV', 'Active or history of bladder cancer', 'Diabetic ketoacidosis', 'Severe hepatic impairment', 'Pregnancy']

Storage

Store below 25°C.

Frequently Asked Questions

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