Amivate-M 5/1500 Tablet
Amitriptyline 5 mg + Methylcobalamin 1500 mcg Tablets — Low-Dose Neuropathic Pain Therapy
| Composition | Amitriptyline 5 mg + Methylcobalamin 1500 mcg |
|---|---|
| Dosage Form | Tablet |
| Pack Type | Alu-Alu Blister |
| Pack Size | 10 x 10 Tablets |
| MRP | ₹ 1485 |
| Therapy | Neurology — Tricyclic Antidepressant + Vitamin B12 Combination (low-dose) |
| Storage | Store below 30 °C in a dry place, protected from light and moisture. |
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About Amivate-M 5/1500 Tablet
Amivate-M 5/1500 Tablet is the lower-strength variant of Trumac’s Amitriptyline + Methylcobalamin combination, containing Amitriptyline 5 mg with Methylcobalamin 1500 mcg. The 5 mg Amitriptyline dose is ideal for elderly patients, those sensitive to anticholinergic side effects, and the initial titration phase of neuropathic pain therapy where tolerability is the primary concern.
The combination provides two complementary effects: Amitriptyline strengthens descending pain inhibition by raising serotonin and noradrenaline neurotransmission, while Methylcobalamin supplies the active form of vitamin B12 essential for myelin synthesis and nerve regeneration. Together they offer both symptomatic relief and underlying neuroregenerative support.
Amivate-M 5/1500 is manufactured by Trumac Healthcare under WHO-GMP conditions and is available for monopoly-based PCD pharma franchise and third-party manufacturing — a popular elderly-friendly neuropathic pain SKU.
Indications
- Painful diabetic neuropathy in elderly or TCA-sensitive patients
- Post-herpetic neuralgia
- Initial titration of TCA therapy for chronic pain
- Vitamin B12 deficiency-related neuropathy
- Cervical / lumbar radiculopathy with neuropathic component
Mechanism of Action
Amitriptyline inhibits serotonin and noradrenaline reuptake in the CNS, enhancing descending pain modulation. The low 5 mg dose produces analgesic benefit with minimal anticholinergic burden. Methylcobalamin serves as a coenzyme for methionine synthase, providing methyl groups for myelin synthesis and homocysteine-to-methionine conversion — supporting peripheral nerve regeneration.
Dosage & Administration
Adults: 1 tablet at bedtime, may increase to 2 tablets daily as needed. Continue for 8–12 weeks or longer. Particularly suited to elderly patients and TCA-sensitive individuals.
Side Effects
Mild drowsiness, dry mouth, constipation, dizziness (less than higher Amitriptyline doses). Methylcobalamin is well tolerated. Rare: hypersensitivity, weight gain.
Contraindications & Precautions
Hypersensitivity to TCAs or Methylcobalamin. Recent MI; cardiac arrhythmias. Concomitant MAOI use (14-day washout). Severe hepatic impairment. Narrow-angle glaucoma. Caution in elderly with cardiac history.
Storage
Store below 30 °C in a dry place, protected from light and moisture.
Amivate-M 5/1500 Tablet is available for monopoly-based PCD pharma franchise across India and for third-party manufacturing under your brand. WHO-GMP certified, with full visual-aid and promotional support. Become a Trumac franchise partner →
Frequently Asked Questions
What is Amivate-M 5/1500 Tablet used for?
Amivate-M 5/1500 is a low-dose combination of Amitriptyline 5 mg and Methylcobalamin 1500 mcg, used for neuropathic pain — particularly in elderly patients or those sensitive to tricyclic side effects.
When should I use Amivate-M 5/1500 instead of 10/1500?
The 5/1500 strength is preferred for elderly patients, those with cardiac history, or as the initial titration dose before stepping up to the 10/1500 strength.
Is Amivate-M 5/1500 available for PCD pharma franchise?
Yes, Trumac Healthcare offers Amivate-M 5/1500 on monopoly-based PCD pharma franchise and for third-party manufacturing.
How should Amivate-M 5/1500 be stored?
Store below 30 °C in a dry place, away from direct sunlight and moisture.
Is Amivate-M 5/1500 WHO-GMP certified?
Yes, Amivate-M 5/1500 Tablet is manufactured in WHO-GMP and DCGI-compliant facilities.
Related Products
- Amivate-M 10/1500 Tablet — Amitriptyline 10 mg + Methylcobalamin 1500 mcg
- Amivate-10 Tablet — Amitriptyline 10 mg
- Amivate-25 Tablet — Amitriptyline 25 mg